Metabolic acidosis caused by increased acid levels due to increased production of acid or acid consumption or substance that can be converted into acid. It also can be caused by: Loss of bicarbonate as in cases of diarrhea and renal tubular acidosis.
Malaria can also be responsible for this condition by destroying red blood cells and thus reduce the level of oxygen in the body. This in turn leads to the accumulation of lactic acid due to anaerobic glucose or carbohydrate details. Acidosis type known as lactic acidosis.
Sometimes, such as pH imbalance can occur even without excessive acid production. For example, in the case of people suffering from kidney failure, the kidneys may fail to remove the acid in the urine. Conditions such as alcoholism and malnutrition are also associated with this condition.
Diabetes mellitus is a common disorder which is characterized by a lack of insulin secretion or insulin resistance by the main target tissues (skeletal muscle, liver, and adipocytes). Severe metabolic acidosis may develop in uncontrolled diabetes mellitus.
Acidosis occurs due to lack of insulin causes a decrease in glucose utilization, diversion of metabolism to the utilization of fatty acids and ketone body production of excess acid.
Severe acidemia, whatever the cause, has many effects on the body. Disruptive change myocardial contractility, resulting in decreased cardiac output. This causes arteriolar dilation, which leads to a decrease in arterial blood pressure. Liver and kidney blood flow is decreased.
Severe acidemia, electrolyte disturbances and volume depletion that accompanies uncontrolled diabetes mellitus can be fatal. Addressing the underlying causes, rather than just treating symptoms best achieve correction of acid-base disturbances. Therefore, the appropriate dose of insulin administration is usually a key element of therapy.